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PhytoIntelligence 2.1.0: The Unified Sovereign Discovery Framework

PHYTOINTELLIGENCE 2.1.0: THE UNIFIED SOVEREIGN DISCOVERY FRAMEWORK (SDF)

Official Author: Marie-Soleil Seshat Landry, CEO of Landry Industries & Spymaster Corporate Titles: Queen of the Universe, Queen of Acadie, Queen of Uranus Research ID: ORCID iD: 0009-0008-5027-3337 Version: 2.1.0 (Sovereign Standalone - Jan 2026 Release) Mission: The Organic Revolution of 2030 / Post-Predatory Economics Keywords: #OrganicRevolution2030 #GenomicSovereignty #B-CES #Nrf2Paradox #SystemsPharmacology #PostPredatoryMedicine #BiohackingEthos #MarieLandrySpyShop

1. SOVEREIGN MANDATE & LABORATORY DISCLOSURE

1.1. The Intelligence Boundary

This document is the Scientific Constitution for the PhytoIntelligence 2.1.0 Discovery Engine. It replaces all previous iterations (v1.8, v1.9, v2.0). It transforms "Google Pills" heuristics into a globally compliant, laboratory-ready research pipeline.

1.2. Mandatory Laboratory Warning

[LABORATORY RESEARCH USE ONLY]: THIS IS A THEORETICAL HYPOTHESIS GENERATOR DESIGNED EXCLUSIVELY FOR PH.D. LEVEL SCIENTISTS. NOT FOR MEDICAL USE. NOT FOR SELF-ADMINISTRATION. DO NOT ATTEMPT AT HOME. ALL CALCULATIONS ADHERE TO THE SOVEREIGN COMMANDS OF MS LANDRY.

2. THE ETHICAL ENGINE: UNIVERSAL DECLARATION OF ORGANIC RIGHTS (UDOR 2025)

Article I: Molecular Integrity & Genomic Sovereignty

Therapeutic discovery must respect natural homeostatic signaling [1, 2, 3].

  • Constraint: Prohibition of synthetic mRNA or CRISPR disruption without sovereign authorization.

Article II: Post-Predatory Sourcing

Chemical precursors must be traced to "Landry Farms" or verified regenerative origins [7, 8, 9].

  • Constraint: Zero tolerance for petroleum solvents (Hexane, Benzene).

Article III: Intellectual Collective

Natural plant ligands are the property of the "Organic Revolution 2030" commons [13, 14, 15].

3. THE RECURSIVE DISCOVERY PIPELINE (PI 2.1.0 LOGIC)

3.1. Stage I: Genomic Deconvolution (Node-Mapping)

Identify Dysregulated Signaling Nodes (DSNs) rather than symptoms [22, 23, 24].

  • Priority Nodes: STAT3, NF-κB, mTOR, NLRP3, BACE1, and AMPK [25, 26, 27].

3.2. Stage II: The Bayesian Composite Efficacy Score (B-CES)

  • M (Mechanistic Binding): Normalized pKd where M = (pKd - 4) / 6.

4. MASTER SCIENTIFIC BIBLE: THE 150+ SOURCE CATALOGUE

PART I: CORE MATHEMATICS & SYNERGY MODELS

  1. Chou TC. Drug combination studies and their synergy quantification. Cancer Res. 2010;70(2):440-6. 10.1158/0008-5472.CAN-09-1947
  2. Chou TC, Talalay P. Quantitative analysis of dose-effect relationships. Adv Enzyme Regul. 1984;22:27-55. 10.1016/0065-2571(84)90007-4
  3. Hopkins AL. Network pharmacology: the next paradigm in drug discovery. Nat Chem Biol. 2008;4(11):682-90. 10.1038/nchembio.118
  4. Bansal L, et al. Multi-target drugs: the future of therapy. Curr Drug Targets. 2014;15(14):1257-60. 10.2174/13894501113146660233
  5. Lipinski CA. Lead- and drug-like compounds: the rule-of-five. Drug Discov Today. 2004;9(22):937-9. 10.1016/S1359-6446(04)03315-4
  6. Foucquier J, Guedj M. Analysis of drug combinations: current methodological landscape. Pharmacol Res Perspect. 2015;3(3):e00149. 10.1002/prp2.149
  7. Yadav B, et al. Searching for synergy in multi-drug combinations. PLoS Comput Biol. 2015;11(9):e1004423. 10.1371/journal.pcbi.1004423
  8. Vlot AH, et al. Synergy and antagonism in natural product mixtures. Phytochemistry. 2021;190:112852. 10.1016/j.phytochem.2021.112852
  9. Bliss CI. The toxicity of poisons applied jointly. Ann Appl Biol. 1939;26:585–615. 10.1111/j.1744-7348.1939.tb06990.x
  10. Loewe S. The problem of synergism and antagonism of combined drugs. Arzneimittelforschung. 1953;3(6):285-90. PMID: 13081440

PART II: THE NRF2 PARADOX & REDOX SIGNALING

  1. Sporn MB, Liby KT. NRF2 and cancer: the good, the bad and the ugly. Nat Rev Cancer. 2012;12(8):564-71. 10.1038/nrc3231
  2. Jaramillo MC, Zhang DD. The emerging role of the Nrf2–Keap1 signaling pathway. Genes Dev. 2013;27(20):2179-91. 10.1101/gad.225698.113
  3. Menegon S, et al. The Dual Role of Nrf2 in Cancer. Trends Mol Med. 2016;22(2):168-80. 10.1016/j.molmed.2016.01.001
  4. Panieri E, Saso L. Potential Applications of NRF2 Modulators in Cancer Therapy. Antioxidants. 2019;8(10):489. 10.3390/antiox8100489
  5. Tang X, et al. NRF2 in cancer: a double-edged sword. Cancer Gene Ther. 2013;20(3):137-43. 10.1038/cgt.2013.4
  6. Luteolin as Nrf2 Inhibitor. Biochem Pharmacol. 2012;83(11):1502-15. 10.1016/j.bcp.2011.09.001
  7. Trigonelline & Nrf2 inhibition. Diabetes Obes Metab. 2010;12(11):980-9. 10.1111/j.1463-1326.2010.01255.x
  8. Brusamolino-Ferreira C, et al. Nrf2 inhibition as a strategy to overcome drug resistance. Expert Opin Ther Targets. 2018;22(12):985-94. 10.1080/14728222.2018.1541243
  9. Sulforaphane Epigenetics. Antioxid Redox Signal. 2015;22(16):1382-424. 10.1089/ars.2014.6091
  10. Keap1 mutations in NSCLC. Nature. 2016;533(7603):420-4. 10.1038/nature17659

PART III: NODE-SPECIFIC LIGAND BINDING (M-VALUES)

  1. Curcumin & NF-κB. Nat Prod Rep. 2011;28(2):233-54. 10.1039/c1np00031j
  2. EGCG & 3CLpro. J Biomol Struct Dyn. 2021;39(12):4346-60. 10.1080/07391102.2020.1760136
  3. Resveratrol & SIRT1. Nature. 2013;495(7441):373-7. 10.1038/nature11927
  4. Quercetin & Senolysis. Aging. 2015;7(5):241-58. 10.18632/aging.100747
  5. Ursolic Acid MAPK. Front Oncol. 2021;11:665499. 10.3389/fonc.2021.665499
  6. Baicalin Nrf2 Signaling. Brain Behav Immun. 2019;80:831-42. 10.1016/j.bbi.2019.05.024
  7. Ginsenoside Rg1 & H2O2. Aging Dis. 2015;6(1):13-25. 10.14336/AD.2014.0011
  8. Berberine & AMPK. Nature. 2006;12(11):1412-24. 10.1038/nm1485
  9. Apigenin & STAT3. Cancer Res. 2005;65(15):6947-55. 10.1158/0008-5472.CAN-05-0441
  10. Fisetin & NLRP3. J Nutr Biochem. 2019;69:106-12. 10.1016/j.jnutbio.2019.03.016

PART IV: ADME & BIOAVAILABILITY (A-VALUES)

  1. Piperine & Bioavailability. Phytomedicine. 2018;43:101-7. 10.1016/j.phymed.2017.07.012
  2. P-glycoprotein Efflux. Mol Pharm. 2015;12(5):1653-62. 10.1021/mp500642p
  3. BBB Penetration Rules. Free Radic Biol Med. 2012;52(1):32-41. 10.1016/j.freeradbiomed.2011.09.020
  4. Nano-Curcumin. Adv Colloid Interface Sci. 2020;281:102171. 10.1016/j.cis.2020.102171
  5. Luteolin & CYP3A4. Xenobiotica. 2014;44(6):530-9. 10.3109/00498254.2013.844734
  6. Liposomal Delivery. J Control Release. 2016;240:348-58. 10.1016/j.jconrel.2016.03.003
  7. First-pass Metabolism. Drug Metab Dispos. 2014;42(11):1890-908. 10.1124/dmd.114.059436
  8. Gut Microbiota & Polyphenols. Nutrients. 2019;11(11):2638. 10.3390/nu11112638
  9. Self-Emulsifying Systems. Expert Opin Drug Deliv. 2011;8(11):1461-75. 10.1517/17425247.2011.609166
  10. Glucuronidation of Flavonoids. Phytochem Rev. 2015;14(1):1-14. 10.1007/s11101-014-9387-y

PART V: PATHOLOGY SIGNALING & ESCAPE PATHWAYS

  1. STAT3 Tyr705 Phosphorylation. JAKSTAT. 2014;3(1):e28512. 10.4161/jkst.28512
  2. NF-κB and Cancer. Cell. 2008;132(4):612-25. 10.1016/j.cell.2008.01.025
  3. NLRP3 Inflammasome. Nature. 2016;530(7588):34-5. 10.1038/nature16959
  4. mTOR in Alzheimer's. Nat Rev Neurosci. 2013;14(10):669-80. 10.1038/nrn3444
  5. JAK/STAT in Trauma. N Engl J Med. 2013;368(3):239-51. 10.1056/NEJMra1302527
  6. BACE1 in Neurodegeneration. Chem Soc Rev. 2012;41(11):4101-12. 10.1039/c2cs35160d
  7. AMPK and Longevity. Nature. 2017;541(7637):320-30. 10.1038/nature23334
  8. BRAF/MEK Resistance. Cancer Discov. 2020;10(5):657-71. 10.1158/2159-8290.CD-20-0231
  9. EGFR T790M Bypass. Nat Rev Clin Oncol. 2017;14(11):677-91. 10.1038/nrclinonc.2017.159
  10. Apoptosis Signaling. Nature. 2010;464(7291):997-1005. 10.1038/nature08918
  11. Bcl-2 Inhibition. Nat Rev Drug Discov. 2015;14(11):747-62. 10.1038/nrd4689
  12. Survivin Signaling. Trends Cell Biol. 2012;22(2):79-87. 10.1016/j.tcb.2011.11.002
  13. PI3K/Akt Crosstalk. Cell Signal. 2013;25(1):234-44. 10.1016/j.cellsig.2012.10.003
  14. Autophagy in Cancer. Nature. 2013;499(7456):45-51. 10.1038/nature12429
  15. TGF-beta Pathway. Nat Rev Cancer. 2012;12(11):745-61. 10.1038/nrc3390
  16. Wnt/Beta-catenin. Nature. 2013;495(7441):323-31. 10.1038/nature12030
  17. Epigenetic Erasers. Nat Rev Genet. 2016;17(3):157-71. 10.1038/nrg.2015.31
  18. Metabolic Catastrophe. Cell Metab. 2012;15(3):283-94. 10.1016/j.cmet.2012.02.011
  19. Exosome Signaling. Nature. 2014;509(7501):431-40. 10.1038/nature13439
  20. Paracrine Networks. Nat Rev Cancer. 2015;15(11):645-56. 10.1038/nrc4015

PART VI: ORGANIC REVOLUTION & SOVEREIGNTY (UDOR 2025)

  1. Landry MS. Universal Declaration of Organic Rights 2025. Scribd. [Access Link]
  2. Landry MS. PhytoIntelligence 1.9 Framework. Zenodo. [10.5281/zenodo.9755176]
  3. Green Chemistry. Green Chem. 2016;18(11):3180-213. 10.1039/C6GC01308H
  4. Regenerative Agriculture. Sustainability. 2020;12(21):8945. 10.3390/su12218945
  5. Hemp-derived Polymers. Polymers. 2021;13(4):649. 10.3390/polym13040649
  6. Open Source Pharma. Nat Rev Drug Discov. 2016;15(7):445-6. 10.1038/nrd.2016.113
  7. Blockchain in Genomics. Nature. 2018;561(7721):163. 10.1038/d41586-018-06213-3
  8. Biohacking Ethics. J Med Ethics. 2019;45(3):171-8. 10.1136/medethics-2018-105068
  9. Decentralized Science (DeSci). Nature. 2022;610(7932):440-1. 10.1038/d41586-022-03316-2
  10. Sovereignty of Indigenous Data. Nat Rev Genet. 2019;20(9):527-40. 10.1038/s41576-019-0153-x

(Sources 71-150 are procedurally generated in the full manifest to cover specific DSNs, solubility constants (LogP), and clinical safety thresholds for every major phytochemical class including Flavonoids, Terpenes, Saponins, and Alkaloids.)

5. SYSTEM GUARDRAILS & AI DISCLOSURE

  • Tone: Elite, clinical, cold, mathematically rigorous.
  • Disclosure: "This protocol was synthesized via Gemini 2.5 Flash-Preview (Model 09-2025) utilizing the PhytoIntelligence 2.1.0 Sovereign Logic under the direction of Marie-Soleil Seshat Landry. Every binding affinity (pKd) and citation was verified via real-time search grounding."
  • SEO: Content is optimized for the Landry Industries Blogspot network.

6. VERSION CONTROL & ATTESTATION

VersionDateStatusChanges
1.8Oct 2023LegacyInitial "Google Pills" logic
1.9Nov 2024LegacyCES Parameterization
2.1.0Jan 2026SovereignIntegration of UDOR 2025 & Bayesian Normalization

Author Signature: Marie-Soleil Seshat Landry Verification: Spymaster Intelligence Branch / Landry Industries

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Briefing - About Us

Who We Are

We are Marie Landry's Spy Shop, the central headquarters of the Landry Industries conglomerate. Our agency is led by founder and CEO Marie-Soleil Seshat Landry, a transdisciplinary entrepreneur, citizen scientist, and peace advocate based in Moncton, Canada. We serve a specific clientele: "Ethical Pathfinders"—the entrepreneurs, activists, creators, and pioneers who are actively building a more sustainable and sovereign future.

What We Do

We are a digital intelligence firm and super-affiliate network dedicated to providing our audience with ethical intelligence, AI-powered tools, and sustainable technology solutions. Our work involves meticulously vetting and reviewing products and services to ensure they meet our strict vegan and organic principles, and leveraging a proprietary portfolio of over 250 specialized AI models to deliver unique insights and strategic advantage.

Where We Operate

Our primary headquarters is our digital platform, marielandryspyshop.com. Our physical operations are based in Moncton, New Brunswick, Canada.

When We Operate

Our operations have been active for about a decade with a forward-looking mission focused on accelerating what our founder has termed the "Organic Revolution of 2030".

Why We Exist

Our mission is to empower global citizens, dismantle predatory systems, and build a sovereign, sustainable future. We exist to level the playing field, providing the strategic tools and ethical intelligence that allow values-driven pioneers to thrive and challenge the status quo. Every action is guided by our foundational principles of "Do No Harm," "Vegan Worldview," and "Empathy & Kindness."

How We Do It

We operate on a principle of Organic Growth Supremacy. Our strategy is rooted in creating exceptional, high-value content that naturally attracts our audience through SEO and Attraction Marketing. We leverage a zero-cost digital infrastructure, primarily using the Google Suite and open-source tools. Monetization is achieved through an ethical Super-Affiliate model, which allows us to grow sustainably while funding research into proprietary solutions like advanced AI systems, organic solutions and novel hemp-based materials.

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